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Numerous endogenous peptides meet fundamental criteria for druggability, including defined receptors, dose-dependent physiological effects, and genetic or pharmacologic validation in preclinical models

It appears to interact with key biological systems, such as the nitric oxide pathway and antioxidant defenses, which may explain its broad therapeutic effects

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It should only be discussed in the context of medically supervised peptide therapy, not self-directed performance use

As GLP-1 RAs are contraindicated for people with gastrointestinal disease, pancreatitis, or a family history of mutations in multiple endocrine neoplasia type 2/medullary thyroid carcinoma (MEN2/MTC), SGLT2i is the preferred treatment for these patients groups