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doi: 10.1038/s41598-020-62157-x 90 Ruiz-PablosMPaivaBMontero-MateoRGarciaNZabaletaA

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1 Due to the nature of invasive surgery coupled with the lack of a laboratory biomarker for the disease, both laparoscopy and laparotomy result in a delayed definitive diagnosis, thus leading to disease progression over time

Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011