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Toxicity evaluations demonstrate an IC50 above 300 g/mL for joint cells and no adverse effects in 28-day in vivo studies

These bark-specific metabolites play critical roles in protecting lignified tissues from oxidative stress and microbial invasion, particularly under conditions of injury or environmental fluctuation (Fontaine et al., 2017

10.1016/j.drugalcdep.2007.04.004 40 OkanoM.SatoM.KageyamaS

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In Mecp2-deficient mice, NTS neurons show significantly reduced amplitudes and frequencies of sIPSCs and mIPSCs, indicating impaired synaptic transmission, and decreased eIPSC amplitudes, though the paired-pulse ratio (PPR) remains unchanged, suggesting that postsynaptic mechanisms may contribute to the weakening of GABAergic inhibition

Genistein reduced the neural apoptosis in the brain of ovariectomised rats by modulating mitochondrial oxidative stress