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Incretin hormones, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), both play important roles in triggering the pancreas to secrete insulin to achieve normal glucose homeostasis, however, for people with diabetes, the pancreas becomes less responsive to incretins (predominately to GIP)
U., and Uzor P
The kinase fusion genes are similar to those that occur in Spitz nevi, but the histopathologic features of congenital nevi with Spitz nevus initiating mutations and their natural history has yet to be determined
In general, it is considered a multifactorial metabolic disease characterized by several clinical manifestations such as hyperandrogenism, polycystic ovaries aspects on ultrasound and ovulatory dysfunctions which makes it the most common cause of anovulation infertility in women, but also from metabolic problems such as obesity, insulin resistance, hyperinsulinemia and type II diabetes which may enhance cardiovascular complications and other neurological and psychological implication such as anxiety and depression [2, 3]
