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Additionally, the condition promotes water retention and reduces physical activity tolerance due to fatigue and muscle weakness

Recent polls show that about 1 in 8 U.S

Shim H, Horner JW, Wu C-J, et al

In OA, however, due to an inflammatory microenvironment and cellular stress, glycolytic flux often becomes further elevated to meet energy demands, while mitochondrial dysfunction may reduce oxidative phosphorylation efficiency (100)