Obinutuzumab, a fully humanized type II anti-CD20 monoclonal antibody that can induce extensive B-lymphocyte depletion, has been evaluated in clinical trials for SLE, particularly focusing on LN (122)
This implies that the FOXO4-p53 interaction effectively induces cellular senescence
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However, more severe oxidative stress can cause cell death, and even moderate oxidation can trigger apoptosis, while more intense stresses may cause necrosis
Liu et al., 2018
Bringing Basic Science Closer to the Clinic Harris emphasized that although the antioxidant glutathione is linked to cancer, it does not mean that individuals should stop eating antioxidant-rich whole foods