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For instance, celastrol demonstrates antifibrotic efficacy in pulmonary models (Zhou et al., 2022), necessitating targeted toxicokinetic evaluations

There remain numerous pending issues to be addressed regarding the pathological diagnostic indicators of T2DM, as well as in-depth mechanistic research and the development and application of clinical drugs

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Front Physiol 10:657

Review supplementation If elevated B12 results from excessive supplementation: Discontinue or reduce high-dose supplements unless medically indicated For patients receiving therapeutic B12 injections for confirmed deficiency, continue treatment as prescribedelevated levels are expected after replacement therapy and do not indicate toxicity Review with GP to ensure supplementation remains appropriate 3

This process is important for healing injured tissues