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Neurodegeneration: redoxproteostasismitochondria triad Neurons operate close to an oxidative edge because they consume large amounts of O 2 , are enriched in polyunsaturated lipids that are easy substrates for peroxidation and rely on long axons studded with far-flung mitochondria that are hard to replace

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Reduced kidney function and folate status are major confounders, since both can raise MMA and/or homocysteine independently of B12

Dietary deficiency of Vitamin B12 can result from poor diets or among strict vegetarians who choose not to consume any animal products

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This activation, in turn, upregulates the vascular endothelial growth factor and promotes angiogenesis (102)