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Rotate injection sites (e.g., abdomen, thighs, back of the arms) to avoid repeated trauma

In another study in healthy and obese-diabetic animal models, allulose also elicited a GLP-1 release, reduced food intake and showed positive effects on glucose tolerance (Reference Iwasaki, Sendo and Dezaki17)

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While tirzepatide does not directly cause specific micronutrient deficiencies through its mechanism of action, the secondary effects on eating patterns and gastrointestinal function warrant attention to nutritional adequacy

Nausea affects up to 20% of semaglutide users and is the most common reason people discontinue treatment (Alhazmi & le Roux 2026, Frontiers in Endocrinology)