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Hormonal changes accelerate oxidative stress, often bringing fatigue, hot flashes, and skin shifts

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The increased production of pro-inflammatory cytokines, such as interleukin 1 or interleukin 8, greatly impacts the biological function of the cells, resulting in skin lesions and deterioration of skin appearance, as well as the accumulation of eumelanin, leading to the formation of skin spots

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Huang Z., Liu Y., Qi G., Brand D., Zheng S.G