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10.1016/0009-8981(82)90045-6 175 McCabeH

Ipamorelin is a selective growth hormone-releasing peptide that stimulates the pituitary gland to release growth hormone in a natural pulsatile pattern

For pigment specifically, a randomized, vehicle-controlled trial found topical tretinoin significantly improved melasma (a randomized vehicle-controlled trial showing topical tretinoin improves melasma), and a separate vehicle-controlled study confirmed the benefit specifically in patients with darker skin (a vehicle-controlled trial of topical tretinoin for melasma in darker skin)

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Chronic Stress and HPA-Axis Dysregulation Ongoing pain is interpreted by the brain as a stress signal

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