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NAC indirectly regulates dopamine release through glutamatergic neurotransmission by binding to presynaptic mGlu2/3 receptors on nerve endings
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In summary, PROTACs represent a burgeoning technology in AD drug development, specifically targeting dysfunctional enzymes, misfolded proteins, and even PPI in AD through the rational utilization of the UPS clearance system
Ca 2+ -regulated extramitochondrial enzymes, such as NADPH oxidases and nitric oxide synthase (NOS) under both physiological and pathological conditions, stimulate ROS formation (Roe et al
