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In this two-tier screening approach, BBB-PAMPA was first employed to eliminate compounds with poor passive permeability, followed by MDR1-MDCK I to screen out P-gp efflux transporters' substrates

although albuminuria is a clinically meaningful biomarker and treatment target, it remains a surrogate endpoint and does not, by itself, prove reduction in kidney failure or need for kidney replacement therapy

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doi: 10.1186/s13023-015-0312-z 61 RosenbergAGWPellikaanKPoitouCGoldstoneAPHybyeCMarkovicTet al

In such cases, your doctor may not prescribe Januvia for you