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This emphasizes the pressing need for more translational research approaches that align with real-world disease progression

Dry foods (kibble) and chunks of raw meats, or even cooked chunks of meats, can cause swallowing problems for toothless dogs

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When the results were published in 2016 in the journal Molecular Psychiatry , the authors cautioned that their findings "should be considered preliminary until treatment is assessed in larger multicenter studies with longer duration." "Jumping the gun" Given the lack of conclusive evidence, many doctors and researchers think it's too soon to be suggesting leucovorin as a treatment