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10.1186/1747-1028-1-8 46 Fors-MartosJ.Catal-LpezF.Snchez-ValleJ.IbezK.TejeroH.Palma-GudielH.et al (2019)
8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs
the FDA advisory committee then voted against permitting their compounding, leaving them restricted (source)
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The glucagon receptor component increases energy expenditure and fat oxidation
Because B12 is water-soluble, extra is excreted rather than stored long term
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