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In any scientific study, the dose is your primary independent variable

May 7 2015;21(17):5359-5371

Foods rich in vitamin B12 also contain high levels of histamine, which can trigger a reaction

View Study [7]"Skin Care Benefits of Copper Peptide Containing Facial Cream (as reviewed in Pickart & Margolina 2018)" Leyden J, Stephens T, Finkey MB, Appa Y, Barkovic S, 2002 Finding: A facial cream containing GHK-Cu applied for 12 weeks to 71 women with photoaging increased skin density and thickness, reduced laxity, improved clarity, and reduced fine lines and wrinkle depth

However, for these systemic applications, high doses are often required to overcome rapid enzymatic degradation and achieve therapeutic tissue concentrations

This is because taking your supplement early may better align with your bodys natural energy cycle and avoid any chance of mild insomnia