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Nevertheless, 3349% of patients do not meet targets for glycemic, blood pressure, or cholesterol control, and only 14% meet targets for all three measures and nonsmoking status (2)

The ADA highlights the benefits of combining GLP-1 receptor agonists with SGLT2 inhibitors, stating: Combined use [of GLP-1 RAs and SGLT2 inhibitors] may be considered for additive cardio-kidney protection

Table 3 summarizes the efficacy and hepatotoxicity risks of commonly used oral systemic treatments, highlighting key clinical outcomes and safety considerations

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For type 2 diabetes (NICE NG28), they are typically used when patients have not achieved adequate control with metformin and lifestyle modifications