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In particular, tirzepatide 15 mg was associated with at least twofold higher odds of study drug discontinuation regardless of comparator
[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management
Physiology of the weight-loss plateau in response to diet restriction, GLP-1 receptor agonism, and bariatric surgery
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That constant background hum, telling them to eat even when they are full, has been turned off