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Nephron 140 , 144147 (2018)

Studies have shown it modulates the expression of over 4,000 human genes shifting the expression profile toward a younger phenotype

Frondoside A downregulates Bcl-2 and survivin, increases ROS production, and promotes cytochrome c release, ultimately triggering mitochondrial apoptosis c release, ultimately triggering mitochondrial apoptosis (127)

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Melatonin is metabolized by hepatic cytochrome P450 (CP450) into 6-hydroxymelatonin