jama glp-1 Glucagon-like peptide-1 (GLP-1) receptor agonists (semaglutide [Wegovy, Ozempic, Rybelsus]) and dual incretin agonists (tirzepatide [Zepbound, Mounjaro]) are medications that reduce food cravings, increase fullness, slow digestion, and can help control From JAMA: #GLP-1 receptor agonist

This leads to low serum levels of glutathione

Various studies suggested the mechanism of action for these compounds in the management of DM

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For semaglutide, tirzepatide, and most long-acting GLP-1 receptor agonists, labels contain a Boxed Warning about thyroid C-cell tumor findings in rodents and contraindications for patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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demonstrated that increased tumour expression of TNF- and TNFR1 is significantly correlated with poor prognosis [390]