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Notably, the expression of Vegfa and Bmp4 was increased by 6.7-fold and 2.7-fold, respectively, in the HFD + Ret group compared to the HFD group

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Ozempic is about to be old news, my colleague Yasmin Tayag wrote in 2023, just before an even more powerful obesity drug, tirzepatide, then best known as Mounjaro, was approved

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The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes