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Since humans cannot break down the purine ring due to evolutionary loss of uricase activity, UA is the end-product of purine nucleotide catabolism

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291,292,293 Myocardial infarction (MI) is the leading cause of CVD-related death

The lack of clinical trials may be attributed to the relatively recent identification of ferroptosis and the ongoing investigations of its mechanistic links to Exos

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PCs ( P11) were seeded into collagen type IV and fibronectin coated dishes in Dulbeccos modified Eagles medium (DMEM, Life Technologies, Thermo Fisher Scientific, USA) supplemented with 20% FBS, 1% Glutamax (Life Technologies) and gentamicin (50 g/ml)