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Beyond initial delivery, pharmacokinetic considerations become increasingly relevant, as prolonged intratumoral retention and moderated release kinetics can extend local drug exposure and increase the effective timeconcentration integral within the lesion [33, 37]

XC- chemokines and their receptors (like XCL1, XCR1), CX3C chemokines and their receptors (like CX3CL1 and CX3CR1) have an up-regulation in mononuclear cells (MNCs) and FLS, respectively, in RA patients (98, 127)

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doi: 10.1007/s00011-011-0323-8