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Curr Opin Neurobiol 2009

The research priorities are clear: Phase I safety trials in healthy volunteers must be completed, followed by Phase II efficacy trials for specific conditions if safety is confirmed

Increasing the expression of HO-1 or improving the function of nitrergic mechanisms through experimental approaches protects against the development of gastroparesis or restores gastric emptying in diabetic mice and rats, respectively [58]

1 To understand whether non-diabetic patients prescribed GLP-1 medications experience similar rates of these gastrointestinal (GI) side effects, we studied 367,439 non-diabetic patients, including 170,842 who were on a GLP-1 medication and 196,597 who were on other weight loss medications

PMID 18765803

Counseling around proper timing of intercourse may be useful