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GLP-2 (T) has shown potential to improve left ventricular function and reduce long-term cardiovascular risks ( 5 )

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Furthermore, most weight-loss drugs yield modest and often unsustainable weight reduction unless coupled with sustained lifestyle changes [13, 53]

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However, individual response variesinfluenced by genetics, metabolic state, and lifestyle factors

As a consequence of heightened oxidative stress induced by Aos, the transient receptor potential melastatin 2, a Ca 2+ -permeable channel expressed on brain cells, opens [89]