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This allows it to directly neutralize reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as hydroxyl radicals, superoxide anions, and peroxynitrite

More than 500 distinct gene mutations have been described, of which 380 have an established role in the pathogenesis of WD[3]

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Tissue distribution studies have shown that schisandrin B [13] and schisandrol B (gomisin A) are distributed throughout several tested tissues and accumulate mainly in the liver and kidneys [13, 14]

Compared with ISOD, Moco deficiency (MocoD) also affects the xanthine pathway and leads to an accumulation of hypoxanthine and xanthine, and low to undetectable uric acid concentrations in blood (see Figure 3 )

Survey of the trans-resveratrol and trans-piceid content of cocoa-containing and chocolate products