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Clinical data shows that starting at 2mg instead of 4mg significantly reduces GI symptom frequency and intensity

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Chen MF, Chen LT, Boyce HW Jr

Jakubiczka-Smorag J, Santamaria-Araujo JA, Metz I, et al

This, in turn, may result in decreased infiltration of inflammatory cells into lung tissues in murine models, alongside lower levels of tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) production, further mitigating tissue damage

What we do know: In one Dutch study when people with IBS or IBD and normal B12 levels were given a daily B12 supplement, they didnt report any significant improvements in fatigue, depression, or quality of life