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& Yao, Y

Thats quite the bar

If one places point LS toward the cleft margin, point CPHIL will be moved higher, and it will be more difficult to level the Cupids bow

Thus, to what extent we can fit theory to the data depends on the accuracy of not only the concentrations as a function of pH, but also on the accuracy of the measured solubility of the very low solubility Nic OH species and, if available, on measuring or calculating the pKa itself