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In a murine model of AD, melatonin diminished GSK3 activity [61], an effect potentially reliant on melatonin receptor MT1, as implied by findings in SH-SY5Y cells [62]

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In parallel, dihydroorotate dehydrogenase (DHODH) and sulfide:quinone oxidoreductase (SQOR) were shown to generate ubiquinol (CoQ 10 H 2 , reduced) within mitochondria using dihydroorotate and selenide, respectively 23,24