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Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells

10.1371/journal.pone.0123454 136 SucicM.LueticK.JandricI.DrmicD.SeverA

An important publication by Aakash Desai and colleagues from various US centres appeared in the Inflammatory Bowel Diseases journal in December 2025

Beyond GLP-1s, AbbVies immunology bet on Skyrizi is paying off: the IL-23 inhibitor posted over 60% growth in both quarters on expanded use in inflammatory bowel disease and ongoing strength in psoriasis

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