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Although malonyl-CoA and long-chain acyl-CoA are believed to regulate GSIS, abrogation of malonyl-CoA formation by overproducing malonyl-CoA decarboxylase in beta cells did not interfere with GSIS, [58] whereas chronic, but not acute, suppression of ACC production by 6080% in INS-1 832/13 cells and isolated islets significantly reduced GSIS [59]
Combing this with other medications that also increase serotonin, such as antidepressants like selective serotonin reuptake inhibitors, or SSRIs, could cause serotonin syndrome
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Fontana et al., 2004)
Lujan, and E.H
eLife 8, e50208
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