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More work in traumatic brain injury models has examined T4s capacity to promote neurogenesis, reduce lesion volume, and improve behavioral outcomes in rodents
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Preclinical studies and clinical trials suggest that antioxidants, such as small thiol molecules (N-acetyl-L-cysteine and carbocysteine), antioxidant enzymes (glutathione peroxidases), activators of Nrf2-regulated antioxidant defense system (sulforaphane), and vitamins, for example, C, E, and D, enhance the endogenous antioxidant system and reduce oxidative stress