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The objective of this review was to perform a systematic review of the beneficial and harmful effects of semaglutide oral tablets (3 mg, 7 mg, and 14 mg) as an adjunct to diet and exercise to improve glycemic control in adult patients with T2DM: as monotherapy when metformin is considered inappropriate due to intolerance or contraindications
102 GLP-1 receptors are found in brain regions that handle reward and pleasure
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Response: We thank commenters for their comments on our proposal
It means that the trials done so far have been small, used different strains, applied different protocols, and produced mixed results that do not yet meet the bar for high-confidence efficacy claims
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