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A retrospective study found significantly elevated levels of transferrin in epileptic children with a history of encephalitis compared to normal controls, indicating that ferroptosis plays a crucial role in oxidative stress-induced epileptiform activity during infantile brain inflammation due to high oxygen consumption, low antioxidant capacity, increased brain iron content, and abundant PUFAs in neuronal membranes (55)

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[DOI] [PubMed] [Google Scholar] 14.Begas P, Liedgens L, Moseler A, Meyer AJ, Deponte M

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Proc Natl Acad Sci 105:1354413549 Valvezan AJ, Huang J, Lengner CJ, Pack M, Klein PS (2014) Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish