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By distribution channel, the drug stores & retail pharmacies segment accounted for a share of 44.68% in 2025

Regarding the direct action of EDCs on the thyroid gland, major targets seem to be the sodium/iodide symporter (Na + /I symporter, NIS), responsible for the active transport of iodine to the thyroid, and thyroperoxidase (TPO), the enzyme indispensable for thyroid hormone synthesis, but EDCs can disturb each step of hormonogenesis [24, 25]

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FIGURE 4 Nuclear factor erythroid 2-related factor (NRF2) is an accepted master regulator participating in the cellular adaptive response to redox or energy stress, which accumulates in nuclear to induce a battery of defensive genes encoding detoxifying enzymes and antioxidant proteins (such as SOD2 and NFB) (Figure 4E) (Tonelli et al., 2018)

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