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GSEA 4.3.2 software was used according to default settings with the following adjustments: number of permutations set to 1,000, permutation type set to phenotype, expression dataset to WikiPathways (34), Chip platform Human set to ENSEMBL_Gene_ID_MSigD8v7.5.1.chip, enrichment statistic set to weighted, and metric for ranking genes set to Signal2Noise