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Sleep quality may decline, leaving patients feeling unrefreshed even after a full nights rest

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2.3.3 Extra-endocrine expression of taste receptors Beyond EECs, it is also important to mention that taste receptors may also be present in the brush cells, a subgroup of solitary chemosensory cells found in the nasal cavity and other regions of the gut, especially where food passes from the fundus to the corpus, and digestive process are initiated, where expression of TAS1R1, TAS1R3, and a-gustducin are involved, suggesting a role in amino acid sensing (60, 78, 79)

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(2023) observed a significant compensatory increase in SQOR expression in mouse kidneys, suggesting that this response exacerbates local H 2 S deficiency and may aggravate metabolic damage in the hypoxic renal microenvironment

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