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Additionally, high levels of fumarate react with the cysteine group of mitochondrial aconitase-2 and iron-sulfur cluster binding protein-2, facilitating cellular metabolic adaptation to stresses 138
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It is approved for individuals with a body mass index (BMI) of 30 or higher, or for those with a BMI of 27 or higher who also have at least one weight-related condition such as high blood pressure, high cholesterol, or sleep apnea
In the last 5 years, commonly used oral medications left their places to intralesional therapies
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Lipid -oxidation: As a result of lipid accumulation, -oxidation of fatty acids by cytochrome P450 enzymes has occurred and generated ROS
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