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those with low capacity will have Michaelis constants close to clinically relevant concentrations

Analytical method development and reference-standard preparation also favour a larger vial, since repeated standard preparations from one batch are more internally consistent than the same work spread across batches

and 4) Oxidative stress and NO bioavailability, since age-related oxidative stress and downregulation of endothelial nitric oxide synthase (eNOS) impair the bioavailability of NO[293], which is likely to contribute to decreased microvascular density

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Accordingly, the first cloned gene for a transporter of sulfur metabolite in plants was a gene for SULTR (Smith et al., 1995)

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