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Tirzepatide, marketed as Mounjaro and Zepbound, adds GIP receptor activation to GLP-1 effects

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Contribution statement All authors significantly contributed to the manuscript and approved the final version for publication

and bremelanotide, a melanocortin 4 receptor agonist (NCT06565611)

I believe these medications have such broad effects because a lot of health problems begin with disruptions in insulin resistance [abnormalities in how the body handles glucose] and inflammation, says Jamy Ard, MD, a professor of epidemiology and prevention at Wake Forest University School of Medicine in Winston-Salem, North Carolina

Research has shown positive results, with participants who had obesity and prediabetes losing 12% to 19% of their body weight, depending on dosage