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As early as 1940, Brewer showed that the absence of trace oxygen was not sufficient for growing strict anaerobes and developed a medium based on sodium thioglycollate, D-glucose (dextrose) and agar 18

10.1016/j.jbior.2017.05.005 [DOI] [PubMed] [Google Scholar] Meng Z., Yu Y., Zhang Y., Yang X., Lv X., Guan F., et al

Enhanced resistance to viruses in nicotiana edwardsonii ColumbiaIs dependent on salicylic acid, correlates with high glutathione levels, and extends to plant-pathogenic bacteria and abiotic stress

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The authors suggested that high levels of mechanical stress and exposure to excess H2O2 interfere with the Smad/TGF-1 pathway, significantly altering ECM remodelling and promoting POP (Zhang et al