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The reasons for these failures often include short in vivo half-life, chemical instability, limited cellular uptake, poor bioavailability, lack of targeted delivery to specific tissues or (sub)cellular compartments, a narrow therapeutic index, and toxicity

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Delkhah explains

That might look like a two-egg veggie omelette, three ounces of chicken breast with a half-cup each of quinoa and roasted broccoli, or a cup of berry, almond milk, and protein powder smoothie

Your body has to convert it before it can be used, and many of the patients who walk in saying Ive taken B12 for years and never felt anything turn out to have been on cyanocobalamin the whole time

Even with this protection, only a fraction of the dose you swallow gets fully absorbed