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If you experience new or worsening pain while on GLP-1 therapy, discussing it with your healthcare provider can help determine the best course of action
GLP-1: The Weight of Speculation
It works by: Blocking the reuptake of serotonin in the brain, increasing the availability of this neurotransmitter in the synaptic space Enhancing serotonergic neurotransmission , which helps regulate mood, anxiety, and emotional responses Sertraline is taken orally, typically once daily, and is metabolised in the liver by multiple cytochrome P450 enzymes, including CYP2B6, CYP2C19, CYP2D6, and CYP3A4
The physiological importance of endogenous GLP-1 in feeding behavior and energy homeostasis is illustrated by rodent studies showing that direct administration of the GLP-1R antagonist exendin(9-39) into the brain increases food intake in satiated rats (2)
This action starts a key process called the cyclic adenosine monophosphate (cAMP) pathway, essential for making melanin
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