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Therefore, a combination of brain energy shortage, mitochondrial dysfunction, and oxidative stress surpassing the bodys antioxidant defenses is recognized as a key element in migraine pathophysiology (45, 46)

Topical application involves clean, dry scalp nightly with 2-3 minute massage and no rinsing

348,349 It is also noteworthy that CTE can lead to atypical astrocyte responses that contribute to recurrent seizures

Maquart et al

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