The thioesterase (TE) domain is able to release the target peptide by either hydrolysis or cyclization 12,15,16 and is supposed to condense tetradepsipeptides, first to produce an octadepsipeptidyl- O -TE and then a decadepsipeptidyl- O -TE, followed by macrolactonization to form the cyclic twelve residue product cereulide 8,9
These systems can integrate multiple functionalities, including cell sorting, imaging, and analysis, making them particularly valuable for drug development applications [6] [2]
indeed, they are strongly involved in cell death pathways, such as apoptosis, necrosis, and autophagy 32 , which cause an important portion of neuronal damage in the perinatal HI event (Fig
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Separate enzyme-linked immunosorbent assays (ELISAs) were used for additional inflammatory, coagulation and BBB markers and included human tissue factor (1:10 dilution, cat
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