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Following the recommended slow dose titration protocol and implementing dietary modifications substantially reduces the incidence and severity of gastrointestinal side effects

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They showed peribronchiolar airway inflammation, accumulation of lymphocytes and eosinophils, elevated IL-5 and IL-6, and airway hyperresponsiveness to inhaled methacholine

For vomiting, tirzepatide posed the highest risk (relative risk 13.22), followed by semaglutide (4.21) and liraglutide (3.87)