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How tirzepatide works Tirzepatide works by mimicking two hormones, GLP-1 and GIP receptors, that help your pancreas release more insulin

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Tirzepatide, which activates both GLP-1 and GIP receptors, tends to produce larger triglyceride reductions than semaglutide alone in head-to-head comparisons, likely reflecting the additional metabolic effects of GIP receptor activation on lipid metabolism

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