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DOI: 10.1213/ane.0000000000007764

Statistical analysis Statistical analysis was performed using parametric two-way mixed model ANOVA (one factor is repeated-measures) and Student Newman-Keuls test to compare the difference between groups

Adverse effects vary by molecule, dose, and patient sensitivity

Fumaric acid accumulation also inhibits the activity of adenylosuccinate lyase (ADSL) in the purine de novo synthesis pathway, resulting in an increase in succinylaminoimidazolecarboxamide ribose (SAICAR) and adenosine succinate, which can cause damage to the central nervous system [84]

The minimum level for B12 is around 180 ng/l however most healthy people have a level of around 500ng/l

Jahanshahi G, Motavasel V, Rezaie A, Hashtroudi AA, Daryani NE, Abdollahi M