MDPI PubMed Nature Claims of differential pro versus anti angiogenic activity derive primarily from animal corneal and tissue injury models and should not be extrapolated to tumor biology without human data
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When homocysteine rises, it can trigger immune cellsespecially monocytes and endothelial cellsto release inflammatory cytokines such as: IL-8 MCP-1 These cytokines recruit immune cells and amplify inflammation throughout the body
10.3390/metabo10110470
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accordingly, strains with a reduced capacity to acquire haem were shown to have a substantially shortened lifespan in broth culture and in chinchilla airways (Maciver et al., 1996