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A decline in blood flow to the kidneys stimulates them to release the enzyme renin, triggering the renin-angiotensin-aldosterone (RAAS) system, and stimulating the reabsorption of sodium and water

Patients report a reduction in post-workout soreness duration, some initial visible changes in muscle fullness from improved glycogen storage, and the beginning of body fat reduction around the abdomen where GH-driven lipolysis preferentially acts on visceral fat stores

[Abstract]2025 Sep;247(6):2871-2884

The activity level of mTORC1 serves as an indicator of disease severity and prognosis [71]

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While this was a post-hoc analysis of an existing trial (not originally designed for aging outcomes), the results are compelling